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Preclinical data robustly support its role in tumor suppression and synergy with conventional therapies, whereas clinical evidence is still preliminary, primarily demonstrating safety and feasibility

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AHK-Cu is a copper-complexed tripeptide formed from alanine, histidine, and lysine residues coordinated with copper

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157,158 The M2d macrophages, also known as TAMs, are activated by TLR ligands and A2 adenosine receptor agonists, and promote tumor progression and metastasis