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doi: 10.3389/fimmu.2021.626217 174 HeJChanTHongXZhengFZhuCYinLet al

Formaldehyde forms various adducts with GSH, among them a cyclic adduct, BiGF 2 ((2S,7R)-7-(carboxymethylcarbamoyl)-5-oxo-9-thia-1,6-diaza-bicyclo [4.4.1] undecane-2-carboxylic acid), containing two equivalents of formaldehyde and one molecule of GSH

Free Radical Biology and Medicine, 160, 471-479

Glutathione works in two distinct ways to support a brighter tone: It inhibits the activity of tyrosinase, which slows down the overall production of melanin