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13 FreiB.EnglandL.AmesB

PCBPs contain three highly conserved hnRNP K homology (KH) domains, which are ancient, RNA-binding motifs broadly distributed in prokaryotes and eukaryotes

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From a three-dimensional structural perspective, SIRT1 is composed of a highly conserved Rossmann-fold catalytic core domain and an additional structural domain comprising both a zinc-binding module and a helical module (Haigis and Sinclair 2010)