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Even more preferably, the second coating further comprises 10 to 80% by weight, preferably 40 to 80% by weight, of one or more selected from triethyl citrate, tripropyl citrate and tributyl citrate, based on the total weight of the second coating

The downstream effects most consistently described in the literature: induction of collagen I and III, elastin, and decorin synthesis (Maquart et al., FEBS Letters , 1988), upregulation of VEGF and basic FGF transcripts, induction of antioxidant defense genes including SOD2 and metallothionein isoforms, and modulation of the MMP-2 and TIMP-1/2 balance toward non-fibrotic remodeling

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