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In preclinical models, the peptide has been linked to angiogenesis, which is the formation of new blood vessels, and to fibroblast activity that drives collagen synthesis in healing tissue

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23 After 6 months of supplementation, 74% in the B12 group had reached no aphthous ulcer status, compared with 32% in the placebo group

If the 2026 preprint holds up through peer review, neuroprotection becomes an equally valid rationale