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Finally, the structures of the selected targets were further checked for their reliability using the same procedure adopted by us in a previous work 45 , in order to select only those targets with the highest possible structural reliability for the following steps

Generally, ROS are by-products of biological metabolism in healthy organisms, though at lower amounts, which activate different signaling pathways to promote survival, proliferation, or resistance to oxidative stress (15)

Foods such as Brazil nuts, eggs, and brown rice are rich in selenium

This demonstrates a cooperative interaction between SeMSN and uricase, enhancing the self-cascade degradation process

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Research has shown that engaging in physical activity can reduce the levels of circulating (plasma) pro-inflammatory cytokines, including IL-1, TNF-, IL-6, IL-8, and IL-10