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As expected, and consistent with a reduced interaction of the amidated C-terminal tyrosine with the CTR ECD, CagriP37Y presented a lower potency than Cagri in cells expressing CTR alone (Supplementary Fig

Consistent with this, cerebellar lesions attenuate cortical readiness potentials [335], and the regional blood flow in the cerebellum correlates with the magnitude of contingent negative variation which predicts the occurrence of relevant events [336]

Women tend to exhibit a slightly higher prevalence of CLBP, particularly after menopause, potentially owing to hormonal influences and differences in pain processing pathways [25,26]