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For the calculation methodology to account for the impact of improper payments in recalculating expenditures and payment amounts used in Shared Savings Program financial calculations, upon reopening a payment determination pursuant to 425.315(a) (described in section III.G.7.c of this final rule), some ACOs will selectively elect to request reopening for a prior performance year

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Many of the circumstances under which we proposed that CMS may withhold to terminate the payments directly relate to circumstances under which we will be concerned that the ACO has not or will not meet the standards for the use of prepaid shared savings, such as an ACO's failure to comply with the requirements of 425.640

"The spectrophysics of warfarin: implications for protein binding"