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However, STAT3 and AKT were unchanged, arguing against parallel activation of signaling pathways

twice as many autophagosomes implies doubled energy expenditures

Free Radic Biol Med 2016;91:1-9

Further corroborating the critical role of C326, we observe that mutating C326 completely abrogates drug-induced proximity of FKBP12 and FBXO22 in intact cells

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