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Through integrated cell-biological, biochemical, and structural analyses, we demonstrate that this gate-locking activity is both necessary and sufficient for cohesion maintenance, operates independently of Pds5 competition, and is tightly regulated during the cell cycle

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Collectively, these data identify TFG as a critical factor upstream of ESCRT-I and thus as having a role early in the ESCRT assembly cascade that enables lysosomal membrane repair

Auguet M, Viossat I, Marin JG, Chabrier PE

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3,76 Glutathione-disulfide reductase then uses electron-catalyzed oxidized glutathione (GSSG) to regenerate GSH