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Environmental pollutant exposure (as discussed in section 4.9) contributes to adipose dysfunction through multiple mechanisms

Chest Med

Mol Cell Biol 2001

To further validate the findings, in vivo experiments were conducted using a mouse model of type 2 DN

This regulation is achieved through Akt substrate of 160kDa (AS160) that produces cellular responses to both Akt and mTORC2 signals to regulate glucose transporter 4 (GLUT4) trafficking during insulin stimulation, and to maintain glucose homeostasis (161)