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In contrast to roGFP2 C151S (SH), 50% glutathionylation of 1 M roGFP2 C208S (SH) required almost 5 M PfGrx C32S/C88S (SSG) (Fig

This requires moving beyond the standard hypothyroidism playbook into an autoimmune-specific strategy

Damage to the mitochondrion that results in release of cytochrome c can stimulate assembly of the apoptosome and activation of the caspase cascade that leads to programmed cell death

417 Oxidized mtDNA is released into the cytosol via mPTP and VDAC-dependent channels on mitochondria, activating the NLRP3 inflammasome and driving a range of inflammatory diseases

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EaglesSmith CA, Silbergeld EK, Basu N, Bustamante P, Daz-Barriga F, Hopkins WA, Kidd KA, Nyland JF (2018) Modulators of mercury risk to wildlife and humans in the context of rapid global change