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Furthermore, it has been demonstrated that higher doses of NAC (18 g/d) have decreasing effects on E2 levels compared with lower doses

When evaluating the quality of the 18 articles 2 , 6 , 11 - 26 selected through the Jadad Scale, their scores ranged between 2 and 5, with a median score of 5 (Table 1)

The treatment usually takes 24 weeks depending on the response

The transcription factor NF-B is an important regulator of immune and inflammatory responses, and NF-B p65-mediated increased trans-activation plays a key role in the pathogenesis of chronic inflammatory diseases (210)

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For many individuals living with complex chronic conditions like Long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and dysautonomia, the daily reality is defined by an invisible, profound energy crisis