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In AD, an imbalance between excitation and inhibition and hyperexcitability of neural circuits particularly in early stages of the disease (Targa Dias Anastacio et al., 2022), caused by the dysfunction of inhibitory neurons (Mohammad Shehata et al., 2022)

Phase 4: Traction Therapy Mechanical Remodeling On the same evening following first injection session, patients begin daily PTT with the RestoreX TM device (PathRight Medical, USA) for a total duration of 90 minutes, consisting of sequential straight traction (15 min) followed by progressive counter-bending at 30 (15 min), 60 (15 min), and 90 (45 min), to optimize mechanotransductive remodeling while preserving treatment tolerability

Mechanistic plausibility does not establish the magnitude, consistency or durability of a visible clinical effect

Liao, X., Pirapakaran, T