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In fact, in physiological conditions, AGEs are formed very slowly while, in particular conditions like hyperglycemia, insulin resistance, obesity, aging, oxidative stress and hypoxia, their formation process is accelerated [33]

LA and/or ALC stimulated mitochondrial biogenesis, up-regulated the expression of PGC-1 and reduced the production of ROS during the 4-week pretreatment Since LA and ALC were withdrawn after a 4-week pretreatment, the question arose as to whether they actively enhanced the antioxidant defence systems for cells to be resistant to the ensuing 4-week rotenone challenge

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