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276 Hajihashemi, P., Askari, G., Khorvash, F., Reza Maracy, M

Additionally, busulfan can decrease Bcl-2 gene expression (as an antiapoptotic gene) and increase Bax gene expression (as a proapoptotic gene) in epididymal sperm of busulfan treated mice, which are related to increased oxidative stress as a result of decreased enzymatic antioxidants of GPx and SOD and increased level of lipid peroxidation in sperm cell (50)

However, the heterogeneity in treatment protocols, such as formulation and dosage of omega-3s used, suggests the need for standardized recommendations in clinical practice [168,169,170,171,172,173,174,175,176,177,178,179]

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Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease

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