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Other effects result from lipoxidation, i.e., covalent binding of electrophilic aldehydes to proteins, or glutathione and nucleic acids, via the reaction of ,unsaturated carbonyl structures with free thiol (illustrated) or amine groups via the Michael addition reaction

Erastin, a ferroptosis inducer, has been used to sensitize GBM cells to TMZ by blocking SLC7A11 and reducing cystathionine--lyase activity

Academic institutions, independent research organizations, or collaborative pharmaceutical initiatives could theoretically pursue these questions, though competitive dynamics make such studies unlikely in the near term

doi: 10.1093/brain/awy147

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