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This warning letter, combined with the broader regulatory environment around GLP-1 compounding, signals that the FDA intends to hold compounding pharmacies accountable (particularly those producing high-profile drug products where patient safety concerns are most visible

Researchers found that inhibiting ornithine decarboxylase, crucial for putrescine production, reduced resistance to 5-FU and enhanced its anti-tumor effects [66]

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Potential Side Effects: Gastrointestinal effects (most common): nausea, vomiting, diarrhea, constipation, abdominal paintypically mild to moderate and decreasing with gradual dose escalation [1] [3]