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Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy

Key ingredients: Niacinamide, collagen extract, glutathione, adenosine, allantoin, centella asiatica extract, amino acid complex, botanical extracts

11 (7), e0158689 (2016)

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5000 MDCK cells were seeded into the wells of a 96 well plates in 10% FBS DMEM

In CYB5R3-deficient conditions, MetHb builds up, glutathione (GSH) levels rise in response to oxidative stress, and RBCs display morphological changes such as microcytosis, acanthocytosis, and increased membrane fragility ( Due to the lack of mitochondria, RBCs depend on the pentose phosphate pathway (PPP) to produce reducing equivalents in the form of NADPH