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Key components that have been successfully manipulated on a regular basis to extend lifespan in short-lived model organisms are, e.g., the growth hormone/insulin-like growth factor 1 (GH/IGF1) system or the mechanistic target of rapamycin (mTOR) pathway (Laplante and Sabatini, 2012

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The results suggest that lithiums inhibition of GSK-3 may prevent pro-inflammatory microglial activation associated with depression, highlighting the Wnt/-catenin pathway as a potential therapeutic target for various neurological disorders [49]