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For those with autoimmune conditions, extra caution is warranted

The diminished protein thiol content, susceptibility to perturbations in methionine metabolism, evidence of chronic low-grade hepatic pathology and occasional spontaneous death in mice with TR/GR-null livers suggest that homeostasis in these animals is at the brink of failure

The study sample size was significantly larger than in previous trials where Vitamin C had no significant impact on prognosis

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