glutathione methylation block The Transulphuration Pathway Understanding MTHFR genetic variation and

Hum Reprod 2025

OShea, T

Originally termed Stein-Leventhal syndrome, PCOS represents a multisystem disorder characterized by intricate associations with metabolic dysregulation and hypothalamic-pituitary-ovarian axis (HPOA) dysfunction, posing substantial threats to fertility during womens prime reproductive years ( PCOS typically manifests during adolescence and is diagnostically characterized by three main features: namely long-term ovulatory dysfunction, hyperandrogenism (HA), and polycystic ovarian morphology, which form the basis of the diagnostic criteria for PCOS (Siddiqui et al., 2022)

Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes

Topp, G

Huang B, Jia Z, Fu C, Chen M, Su Z, Chen Y