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Crit Rev Eukaryot Gene Expr

5.3 Recurrent implantation failure and recurrent pregnancy loss Clinical entities such as recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) may be at least partially attributed to an underlying endometrial factor

Inhibiting the RAS-RAF-MEK-ERK pathway could reduce FECH activity by downregulating hypoxia-inducible factor (HIF)-1 to enhance PpIX accumulation 28,29

From both chemical platforms 40 and 41 , compounds 42 and 43 were identified as the most active and selective of the compounds, respectively, although they were sufficiently active for further assays

10.1111/j.1651-2227.1981.tb05729.x 56

Cornelissen, A