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coli DH5 and BL21 (DE3) pLysS were used as cloning host and expression host respectively

Kadia T, Ravandi F, Daver N, Borthakur G, Cortes JE, Jabbour E, Kornblau SM , Verstovsek S, Weida W, Burger JA, Estrov Z, DiNardo C, Dong XQ, Pemmaraju N, Ohanian M, Takahashi K, Hendrickson S, Kantarjian H, Garcia-Manero G

Excessive fructose catabolism in the liver has been shown to drive the gene expression of DNL enzymes 22,23

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Often this results in increased water solubility of the drug or other foreign molecule, allowing for the more efficient excretion from the organism