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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

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Satiety: a gut-brain-relationship

Maintaining weight loss after discontinuation is possible but challenging for most people, especially those with genetic predisposition to obesity