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doi: 10.1176/appi.ajp.2012.12050627 252 PolicicchioSWasherSVianaJIatrouABurrageJHannonEet al

Overexpression of miR-506 in cholangiocytes leads to multiple PBC-like features, including impaired cell proliferation and adhesion, sensitization to bile acid-induced apoptosis, impaired energy metabolism, PDC-E2 overexpression and mislocation into the plasma membrane, and immune activation

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Each pathway is interlinked through ROS or other intermediates

Current Research in Green and Sustainable Chemistry, 8 , Article 100409