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ATF4 associates with amino acid response elements (AARE) and promotes the transcription of genes related to amino acid metabolism and stress response, in particular SLC7A11, thereby enabling cells to cope with amino acid-limited conditions (Koppula et al., 2021b)

Norberg, E., Orrenius, S., and Zhivotovsky, B

This death mode is more conducive to the release of DAMPs such as HMGB1 than apoptosis, and has a natural pro-inflammatory advantage

Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequency of administration and thereby potentially patient compliance

Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis

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