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A few commenters noted that CMS stated in the initial Medicare Part D Drug Inflation Rebate Guidance that requiring a 340B indicator be included on the PDE record is the most reliable way to identify drugs that are subject to a 340B discount that were dispensed under Medicare Part D

Br J Cancer 85(4), 473-483

If a medication is approaching expiration and will not be used in time, patients should contact their pharmacy or healthcare provider rather than using expired medication