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Immunological and gene therapy approaches to prevent this complication are under development and appear promising (Bertelmann 2001

Additionally, the lack of methylation impairs the brain's ability to clear out neurotoxic metabolites, allowing them to accumulate and disrupt neural signaling

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In vitro experiments adding ferrous ions to spinal neuronal cultures showed that the quantity of lipid peroxidation metabolites correlates directly with iron levels and is positively associated with neuronal inactivation (Galluzzi et al., 2012)

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