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Several international guidelines (from the National Institute for Health and Care Excellence, the New Zealand Ministry of Health, the Royal Australian College of General Practitioners, and the Haute Authorit de Sant de France) advise that e-cigarettes may be used for cessation in certain cases but that information should be provided on the risks and uncertainties, including that e-cigarettes are not licensed medicines in most jurisdictions, and that there is a lack of evidence on long-term harms.95 , 97 99 The Australian and French guidelines suggest that other therapies should be considered first.97 , 99 The United States Preventive Services Task Force judged that the evidence on e-cigarettes was insufficient and recommends directing patients to interventions with proven effectiveness and safety.94 Gaps in knowledge Large comparative trials101 will likely refine future recommendations

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One study found that 70% of its 1,927 participants were still smoke-free 24 weeks later, compared to just 49.6% of a placebo group

At the outset, he was a Chicago phenom, a local hero, and thus had weird champions for a country or folk artist: Roger Ebert famously wrote the first piece on him, and John Belushi kept nagging Saturday Night Live to book him