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In contrast, metE formulated with AddaS03 elicited a mixed immune response with a moderate Th1 CD4+ T cell response marked by TNF- and IL-2 expression and a prominent Th2-skewed response, as evidenced by significantly increased IL-4 production compared to nave group ( Figures 5A, B )

In our study, FOXO4-DRI was found to effectively promote apoptosis in senescent cells by blocking the FOXO4-P53 interaction and facilitating P53 phosphorylation