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Interestingly, although mice exhibiting delirium-like behavior after general anesthesia and surgical laparotomy showed distinct gut microbiota dysbiosis, transplanting gut microbiota from mice without delirium to those exhibiting delirium-like behaviors improved cognitive symptoms (Zhang et al., 2019)

5-Amino-1MQ functions as a small-molecule inhibitor of NNMT, the enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide

Copper chaperone for superoxide dismutase co-aggregates with superoxide dismutase 1 (SOD1) in neuronal Lewy body-like hyaline inclusions: an immunohistochemical study on familial amyotrophic lateral sclerosis with SOD1 gene mutation