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Importantly, HO-1 can be targeted pharmacologically by interventions that seek its upregulation or enhancement of its various arms of action, via: (1) induction of HO-1 expression with drugs such as heme arginate, (2) administration of CO by inhalation or use of CO releasing molecules (CORM), and (3) administration of biliverdin/bilirubin or use of inhibitors of bilirubin conjugation that would result in increased bilirubin levels

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The term "pharmaceutically acceptable salt" includes salts of the active compounds that are prepared with relatively nontoxic acids or bases, depending on the particular substituents found on the compounds described herein

Dieser reichhaltige Pool dient neben der zahlreichen Funktionen des Glutathion auch als Speicher fr das in geringerer Menge vorhandene Cystein

Ferroptosis is a type of non-apoptotic cell death that can be triggered by iron accumulation and lipid peroxidation [9, 10]

In a contrasting mechanism, lncRNA lncCCLM is a potential tumor suppressor in cervical cancer, interacting in the cytoplasm with the RNA-binding protein STAU1 to promote its binding and degradation of IGF-1 mRNA (Fig