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Controlled-release Optimization Physicochemical property regulation By adjusting the physicochemical properties of the drug and the carrier, such as the intermolecular interaction forces and the porosity of the carrier material, the controlled release of the drug can be achieved

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Vedaei et al ., [20] also differed from others by the reporting of changes in direct functional connectivity of the DMN and sensorimotor networks, a finding bolstered by hypothesised activation of the GSH pathway and modulation of mitochondrial function

[12] In an uncontrollled clinical trial, sulbutiamine was reported to be effective in reducing fatigue in patients with multiple sclerosis