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Still treatment with rhIGF-1 may be as efficient as in patients with confirmed homozygous GHR defects (131)

Moreover, alcoholics may experience reduced intestinal absorption of vitamin B 12 (2), and individuals with acquired immunodeficiency syndrome (AIDS) appear to be at increased risk of deficiency, possibly related to a failure of the IF-B 12 receptor to take up the IF-B 12 complex (3)

This distinction affects how the compound is absorbed, metabolized, and utilized in the body