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HIFs are vital at all key stages of metastatic dissemination, for example, processes such as local migration within the tumor and invasion of the surrounding stromal tissue by inducing an EMT-like process and remodeling the extracellular matrix [228]

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It was noted earlier that NAPQI is highly electrophilic in nature which means that there should be positively charged regions on the other side of NAPQI (which is in fact found on the other side of the molecule

When freeze-drying is performed without a protective matrix (such as sucrose or mannitol), residual bound water may cause collapse during the final drying stage