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Correction of the DNA synthesis defect in vitamin B12 deficiency by tetrahydrofolate: evidence in favour of the methyl-folate trap hypothesis as the cause of megaloblastic anaemia in vitamin B12 deficiency

Various disease states are characterized by disturbed metal homeostasis, such as hemochromatosis (iron overload) and flavonoids in the presence of iron (or other redox metals) behave as prooxidants, increasing the total amount of ROS (Valko et al

In proof of the concept that GPx-1 may be a target for kinase phosphorylation, GPx-1 was shown to be a substrate for the tyrosine kinases, c-Abl and Arg, which are important in the cellular response to oxidants (52)

Andrades, R

Inflammation 45 (4): 18151828

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