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Mechanistically, LECs associated with lymphangiogenesis in tumors or the draining LN promoted immune tolerance by eliminating anti-cancer CD8+ cells (95) and accelerating T cell egress (97)

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Finally, NETosis requires both oxidative burst and PAD4 activation, events are dispensable for apoptosis

Figure 4 Mitochondrial superoxide is an important intracellular source of reactive oxygen species and plays a critical role in promoting Fenton/Haber-Weiss reactions by releasing iron from intracellular ferritin complex, which in turn culminates in the generation of highly reactive hydroxyl radicals (6973)