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Later, the PTWI was amended to a tolerable monthly intake (TMI) of 25 g per kg body weight per month (0.83 g per kg body weight per day), and E Cd /E cr of 5.24 g/g creatinine was assigned as a threshold level [4]

Afonina IS, Van Nuffel E, Beyaert R

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In the brain, HIF-1 signaling is associated with neuroprotection, promotion of metabolic adaptation, and neuronal survival

This constant production of free radicals by skeletal muscle requires the buffering capacity of an endogenous defense system, and a multitude of mechanisms have evolved to detect and respond to elevated oxidant production

Patronek GJ, DJ Waters, LT Glickman