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Primary search terminology included esculetin, 6,7-dihydroxycoumarin, and cichorigenin, combined with disease-specific or mechanism-based terms including esculetin AND inflammation, esculetin AND cancer, esculetin AND diabetes, esculetin AND antioxidant, coumarin AND bioavailability, and coumarin AND derivatives. Disease-specific searches incorporated relevant MeSH headings (neoplasms, cardiovascular diseases, diabetes mellitus, neurodegeneration, and hepatic/renal disorders)

doi: 10.1159/000046687

Tanda, M., et al

They act as targeted signals, biological messages that tell a specific type of cell to perform a specific task, such as producing more of a structural protein or supporting repair in a particular tissue

For loose skin specifically, this is huge

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