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Description

Supplementary Table S7)

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Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links

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Early symptoms of the disease can precede the diagnosis by several years, and include constipation (the most common early symptom), REM sleep disorder, hyposmia (smell impairment), pain, and depression (11)

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2.4 Histopathological evaluation The other hemimandibles of each animal were collected and post-fixed for 24 h in 4% formaldehyde

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