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Int J Mol Sci 24(6):5600 Zhou B, Lin W, Long Y, Yang Y, Zhang H, Wu K et al (2022) Notch signaling pathway: architecture, disease, and therapeutics

It is very likely, therefore, that HIF-1's oxygen responsiveness resides over a permissive range of antioxidant buffering capacities, with the demonstration that the antioxidant/pro-oxidant equilibrium effectively uncouples HIF-1 activity from the normal pattern observed in response to variations in p O 2 in the alveolar epithelium [13, 14, 82]

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and (3) the capacity for trilineage differentiation into osteogenic, adipogenic, and chondrogenic cell types under specific inductive conditions

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However, strict GH control of IGF-I in the human fetus would predict severe growth retardation of the above-mentioned genetic defects comparable with the birth size observed in defects in the IGF-I gene