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Targeting predictions (TargetP [45, 46], LOCALIZER [47] and PredAlgo [48], Additional file 1 Table S1) as well as the presence or absence of N-terminal sequence extensions suggest a high variability in subcellular targeting

Carfilzomib (Kyprolis ) is a 2 nd generation, irreversible inhibitor of the 20S proteasomal subunit

Qian X, Li G, Asmussen HK, Asnaghi L, Vass WC, Braverman R, Yamada KM et al