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It has since been repurposed as a precision therapeutic agent for acute promyelocytic leukemia (APL), where it can induce deep and often curative remissions [1,2]

Similarly, a mutation in AXIN2 identified in colorectal cancers promotes GSK3 inhibition and stabilization of Snail, a positive regulator of Wnt signaling (Mazzoni et al., 2015)

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The authors observed a nearly identical half-life for N -Gly-l-homothiaLys and naturally occurring N -Gly-l-Lys, with site selectivity maintained for different isopeptidases

Q.ChengK.IppolitoM.et al

They are frequently referred to as GHK-Cu in the scientific community