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10.1073/pnas.2116415119 Proc Natl Acad Sci U S A

Nature 514 , 380384 (2014)

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This inhibitory function of -catenin on NF-B activity has been observed in numerous cell types, such as fibroblasts, epithelial cells, hepatocytes, and osteoblasts 102

For instance, some studies have suggested differences in preference of IR and IGF1R for different insulin receptor substrates (IRS) 14 , and others have suggested that insulin and IGF-1 are able to induce overlapping, but distinct, patterns of gene expression 15,16,17