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For example, second and third generation anaplastic lymphoma kinase inhibitors, brigatinib and lorlatinib, respectively, have also been unsuccessful in the treatment of primary brain tumors, despite achieving intracranial responses in the treatment of metastatic non-small cell lung cancer (124)

In mature spermatocytes, mtDNA molecules may increase in response to higher ATP demand, providing energy reserves for sperm motility [66, 67]

Non-heme iron in humans is located intracellularly in ferritin, but, despite this large iron reserve, most pathogens are unable to scavenge iron from ferritin

Sometimes its hormonal

63 Advanced imaging techniques, such as magnetic resonance imaging (MRI) and ultrasound elastography, offer detailed views of the ACLs internal structure and its response to mechanical forces

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia