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Instead, they jointly regulate the metabolic fate of immune cells through spatiotemporally dynamic interactions

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Epub 2017 Feb 13 Joseph AW, Joseph SS, Francomano CA, Kontis TC

As it is well established that spatiotemporal control of RhoA activation is heavily dependent upon the localization of GEFs to specific sites within the cell, we hypothesized that DP acts as a scaffold for a RhoGEF at cardiac cell junctions

The role of moderate aerobic exercise as determined by cardiopulmonary exercise testing in ALS

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function