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Gutierrez MG, Munafo DB, Beron W, Colombo MI

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Cell Signal 69 , 109553 (2020)

m.DurandA.LyneA.-M.LandraginC.TrouchetA.et al (2022)

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AGEs are ligands of the receptor for advanced glycation end products (RAGE) and induce inflammation by activation of the nuclear factor B (NF-B) pathway in all neural cells ( Elevated MG seems to increase the expression of astrocyte markers (glial fibrillary acidic protein GFAP and S100B) and cytokines in astrocyte culture and in vivo , leading to astrogliosis and neuroinflammation ( Elevated MG and AGEs levels play a key role in protein misfolding and oxidative stress, and are also involved in AD ( in vitro models, MG induced glutamatergic excitotoxicity by promoting glutamate release ( In PD, a predictor event is the low activity of neuronal PPP enzymes (Vicente Miranda et al., 2016)