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Moreover, as NFAT is not directly activated by LPS, the only signaling pathway in this study that is both inhibited by AM404 and activated in microglia following stimulation with LPS is NF-B [30,68]

Indeed metformin inhibits the mitochondrial oxidative phosphorylation complex I, leading to increased cellular AMP levels and subsequent stimulation of AMPK, an enzyme that plays key roles in the regulation of cellular energy homeostatis

This modulation of the inflammatory phase facilitates the transition to the actual repair phase