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J Neuroinflammation 17:89

Alignments and genome-wide in-depth phylogenetic analyses showed that a gene fusion occurred possibly during the evolution in bacterial species 4 and that EgtA from A

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doi: 10.1016/j.cell.2014.09.032 57 WinkDAMitchellJB

TMEM106 gene deletion downregulates V0a1, V0c and V0d1, and dramatically exacerbates central nervous system neurodegeneration and autophagic stress when combined with loss of PGRN in mice, presumably compounding the acidification deficit common to both genetic manipulations 179181

Among the most striking observations was a downregulation of glycolysis in cetuximab and combo-treated cells at early time-points, while proteins related to iron metabolism, such as ferritin and transferrin receptor TFRC, were respectively up and downregulated in VitC and combo-treated cells at later time-points